More pieces to the iron chelation puzzle

Hereditary breast cancer: ever more pieces to the polygenic puzzle

Several susceptibility genes differentially impact on the lifetime risk for breast cancer. Technological advances over the past years have enabled the detection of genetic risk factors through high-throughput screening of large breast cancer case-control series. High- to intermediate penetrance alleles have now been identified in more than 20 genes involved in DNA damage signalling and repair, ...

Two more pieces to the 1000-piece carbohydrate puzzle.

Healthy diets are high in carbohydrate. The Acceptable Macronutrient Distribution Range for carbohydrates is 45–65%. A maximum intake of 25% of added sugars is suggested. Americans should choose fiber-rich foods such as whole grains, vegetables, fruit, and cooked dry beans and peas as staples in the diet. Dairy products are also a nutrient-dense source of carbohydrates. Carbohydrates are the pr...

Attractin' more attention - new pieces in the obesity puzzle?

Genetic, biochemical and pharmacological studies in humans and rodents have established that signalling through the G-protein-coupled melanocortin-4 receptor (MC4R) by pro-opiomelanocortin (POMC)-derived ligands plays a critical role in the central suppression of appetite. As a consequence, malfunction of this signalling system leads to the development of obesity. It has been shown previously t...

Multiple sclerosis: more pieces of the immunological puzzle.

www.thelancet.com/neurology Vol 11 January 2012 9 During 2011 we have seen important progress in the understanding and treatment of multiple sclerosis (MS), particularly with regard to the role of the immune system. Infl ammatory and neurodegenerative disease mechanisms are both implicated in MS, but whether these happen in sequence or are independent is still under investigation. The fi ndings...

More pieces of the platelet activation puzzle slide into place.